New method of monitoring to prevent additional brain injury for patients in ICU

A2002727

Traumatic brain injury is a leading cause of death and long-term disability, particularly in young adults. The mainstay of TBI management involves admission to the intensive care unit to monitor and minimise additional brain injury caused by increases in intracranial pressure.  Some clinicians feel that rises in intercranial pressure may be a late indicator of secondary damage to brain cells, and small trials have suggested that monitoring and optimising the level of oxygen in brain tissue could be effective in minimising secondary injuries.

The BONANZA study is a multinational randomised controlled trial comparing standard management of raised intracranial pressure with monitoring and optimising brain tissue oxygen levels in patients who have sustained traumatic brain injury. Functional and neurological outcomes will be assessed at 6 months post injury to determine if there is a difference between the two groups. 

Lead Researcher	Dr. Andrew Ratcliffe Consultant in Intensive Care Medicine
Co-Researchers	Mr William Bolton NIHR Academic Clinical Fellow in Neurosurgery
Host Organisation/CSU	Adult Critical Care Leeds Teaching Hospitals NHS Trust
Grant Amount	£8,000
Start Date	01/02/2024
Estimated Duration	24 months
Impact Areas	Innovation & Health Technologies
Tags/key notes	Injuries and accidents