PIEZO1 in Liver Regeneration: Activation in scenarios of liver ischaemia, small for size syndrome, changes in portal vein flow and ultrasound treatment. Variations of PIEZO1 expression in different ethnic backgrounds.

A2003260

This study examines how the liver regenerates after major surgery, focusing on the protein PIEZO1, which detects changes in blood flow and may trigger regeneration. Tissue samples from patients undergoing liver surgery are analysed to identify key genes involved in the regeneration process. The goal is to improve understanding of liver regrowth, predict which patients will recover well, and develop better treatments to prevent liver failure after surgery. Early results show successful patient recruitment and sample analysis. Findings will inform surgical care.

Lead Researcher	Mr Charalampos Konstantinou Clinical research fellow
Co-Researchers	Miss Shaili Patel
Host Organisation	Leeds Teaching Hospitals NHS Trust
Grant Amount	£10,000.00
Start Date	01/03/2025
Estimated Duration	35 months
Impact Areas	Health inequalities - Cancer Care
Tags/key notes	Cancer and neoplasms