Understanding the side effects of radiation treatment for recurring prostate cancer

A2002239

Dr. Ann Henry and her team are exploring the best treatment options for prostate cancer that has recurred within the prostate. Prostate cancer is the most common cancer for men in UK and while radiation treatment cures many, some patients experience a recurrence of cancer. The team aims to determine whether a second course of radiotherapy, either internally via brachytherapy or externally using external beam radiotherapy, is more effective than other treatments like surgery.

The study will assess patient willingness to participate and identify suitable candidates from hospitals in Manchester and London. Participants will be randomly assigned to receive either external beam radiotherapy or brachytherapy. Following treatment, they will have regular follow-up appointments, complete questionnaires, and undergo MRI scans at one month and one year.

Biopsy samples taken during routine care will help uncover new information on tailoring treatments based on the genetic makeup of the cancer. Participants may also provide blood and urine samples to explore how radiotherapy affects the immune system.

This research aims to understand the side effects experienced by patients, providing better information for future patients. The findings will inform the design of a larger clinical trial to determine the most effective treatment for recurrent prostate cancer with the fewest side effects.

Lead Researcher	Dr Ann Henry
Co-Researchers	Dr Jim Zhong Prof Sarah Brown Mr Peter Bownes Mr Chris Thompson
Host Organisation/CSU	Oncology Leeds Teaching Hospitals NHS Trust
Grant Amount	£40,520
Start Date	02/11/2022
Estimated Duration	48 months
Impact Areas	Health inequalities – Cancer Care
Tags/key notes	Cancer and neoplasms